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Pinky and the Brain poster

Shows that feel likePinky and the Brain (1995–1998)

Pinky and Brain are genetically enhanced laboratory mice who reside in a cage in the Acme Labs research facility. Brain is self-centered and scheming; Pinky is good-natured but feebleminded. In each episode, Brain devises a new plan to take over the world, which ultimately ends in failure, usually due to Pinky's idiocy, the impossibility of Brain's plan, Brain's own arrogance, or just circumstances beyond their control.

If you loved Pinky and the Brain, the closest series we have are Animaniacs (1993), Full House (1987) and Frasier (1993). All three share Pinky and the Brain's witty and playful feel, which is what we rank on before quality.

Seen the big three already? The under-the-radar pick below is Una familia de diez (2007).

10 of 12 streaming nowAmazon Prime Video · Hulu · Disney Plus

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If Pinky and the Brain hit the spot, these will too

Animaniacs poster
Animaniacs
1993–1998 · 5 seasons · The WB
★ 7.8animation · kids · comedy

The same preoccupation in both: world domination

The difference: Takes it somewhere less cerebral than Pinky and the Brain does

The two Warner Brothers Yakko and Wakko and their Warner sister Dot had been (supposedly) created in the 1930's, but their cartoons were too screwy for the general public to handle. The three Warners were locked up in the studio water tower until they escaped in the 90's. There, they run wild, causing chaos everywhere!

Full House poster
Full House
1987–1995 · 8 seasons · ABC
★ 6.8comedy · familyHulu

One thread runs through both: friends

The difference: Trades the ideas of Pinky and the Brain for an angle of its own

After the death of his wife, Danny enlists his best friend and his brother-in-law to help raise his three daughters, D.J., Stephanie, and Michelle.

Frasier poster
Frasier
1993–2004 · 11 seasons · NBC
★ 8.2comedy · familyPrime VideoHulu

Witty and playful in the same breath

After many years spent at the “Cheers” bar, Frasier moves back home to Seattle to work as a radio psychiatrist after his policeman father gets shot in the hip on duty.

Una familia de diez poster
Una familia de diez
2007–2026 · 13 seasons · Las Estrellas
★ 7.5comedy · drama · kids

Both land warmth and comfort at once

The difference: Leans harder into drama than Pinky and the Brain does

Ten members of the same family share a small house and stumble together through life's mishaps.

The Nanny poster
The Nanny
1993–1999 · 6 seasons · CBS
★ 7.2comedy · familyPrime VideoHulu

Witty comedy in both cases

That flashy girl from Flushing with the heart of an angel (and the voice of a slighty more nasal angel). The comic misadventures of the sweet and sassy Fran Fine, her sophisticated employer, Broadway producer Mr. Sheffield, his boisterous brood and his wisecracking staff.

Dinosaurs poster
Dinosaurs
1991–1995 · 4 seasons · ABC
★ 7.5sci-fi & fantasy · comedy · familyDisney+

The same mix in both: ideas, then dream logic

Dinosaurs follows the life of a family of dinosaurs, living in a modern world. They have TV's, fridges, microwaves, and every modern convenience.

Vecinos poster
Vecinos
2005– · 21 seasons · Distrito Comedia
★ 7.2comedy · family · kids

Family built on play, twice over

The everyday life of people in Mexican neighborhoods, where anything can be found. Each episode interacts between these peculiar neighbors, where they encounter real and fictitious problems.

Sabrina, the Teenage Witch poster
Sabrina, the Teenage Witch
1996–2003 · 7 seasons · ABC
★ 6.7comedy · family · sci-fi & fantasyHuluParamount+

Sci-fi & fantasy with a pulse of warmth, in both cases

On her sixteenth birthday, Sabrina Spellman discovers she has magical powers. She lives with her 600-year-old aunts Hilda and Zelda as well as talking cat Salem in the fictional town of Westbridge, Massachusetts.

Courage the Cowardly Dog poster
Courage the Cowardly Dog
1999–2002 · 4 seasons · Cartoon Network
★ 8.3animation · family · sci-fi & fantasy

Cozy animation, and it commits to that

The bizarre misadventures of a cowardly dog named Courage and his elderly owners in a farmhouse in Nowhere, Kansas.

Phineas and Ferb poster
Phineas and Ferb
2007– · 6 seasons · Disney XD
★ 8.1animation · comedy · familyDisney+

Both lean on ideas more than on kids

Each day, two kindhearted suburban stepbrothers on summer vacation embark on some grand new project, which annoys their controlling sister, Candace, who tries to bust them. Meanwhile, their pet platypus plots against evil Dr. Doofenshmirtz.

ALF poster
ALF
1986–1990 · 4 seasons · NBC
★ 7.4comedy · family · sci-fi & fantasyPrime VideoPeacock

Dreamlike comedy, and it commits to that

A furry alien wiseguy comes to live with a terran family after crashing into their garage.

Hannah Montana poster
Hannah Montana
2006–2011 · 4 seasons · Disney Channel
★ 5.5comedy · familyDisney+

Both lean on wit more than on family

At home and school, she's Miley Stewart, a typical teenager, but when the lights go down and the curtain goes up, she emerges as the glamorous and talented Hannah Montana. Having the "Best of Both Worlds" is a complicated proposition, and keeping her identity under wraps leads Miley and her friends into some hilarious capers as she tries to balance her normal life with her rock star persona.

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The best-reviewed series that share Pinky and the Brain’s defining feeling.