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Movies that feel like Splice (2010)

If you loved Splice, the closest films we have are In the Tall Grass (2019), Spring (2014) and Deep Blue Sea (1999). All three share Splice's dread and unsettling feel, which is what we rank on before quality. 10 of the 12 picks below are included with a subscription right now on Netflix, HBO Max and Amazon Prime Video and others, checked against today's data.

Elsa and Clive, two young rebellious scientists, defy legal and ethical boundaries and forge ahead with a dangerous experiment: splicing together human and animal DNA to create a new organism. Named "Dren", the creature rapidly develops from a deformed female infant into a beautiful but dangerous winged human-chimera, who forges a bond with both of her creators - only to have that bond turn deadly.

πŸ… 75% Rotten Tomatoesβ˜… 5.8 IMDb β†—TMDB β†—dir. Vincenzo Natalidreadunsettlingcerebral

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If Splice hit the spot, these will too

In the Tall Grass poster
In the Tall Grass
2019 Β· dir. Vincenzo Natali
πŸ… 36%β˜… 5.5horror

Vincenzo Natali working the same nerve twice

The difference: Reviewed a good deal more coolly

After hearing a child screaming for help from the green depths of a vast field of tall grass, Becky, a pregnant woman, and Cal, her brother, park their car near a mysterious abandoned church and enter the field, discovering that they are not alone and, for some reason, they are unable to escape a completely inextricable vegetable labyrinth.

Spring poster
Spring
2014 Β· dir. Aaron Moorhead
πŸ… 85%β˜… 6.7horror Β· romance Β· science fiction

Both land dread and unease at once

The difference: Leans harder into romance than Splice does

A young man in a personal tailspin flees the US to Italy, where he sparks up a romance with a woman harboring a dark, primordial secret.

Deep Blue Sea poster
Deep Blue Sea
1999 Β· dir. Renny Harlin
πŸ… 60%β˜… 5.9action Β· horror Β· science fiction

Both keep coming back to the same thing: genetic engineering

Researchers on the undersea lab Aquatica have genetically altered the brains of captive sharks to develop a cure for Alzheimer's disease. But there's an unexpected side effect: the sharks got smarter, faster, and more dangerous. After a big storm damages their remote research facility, they must fight for their lives.

Annihilation poster
Annihilation
2018 Β· dir. Alex Garland
πŸ… 88%β˜… 6.8science fiction Β· horror

Common ground: dna

A biologist signs up for a dangerous, secret expedition into a mysterious zone where the laws of nature don't apply.

The New Mutants poster
The New Mutants
2020 Β· dir. Josh Boone
πŸ… 36%β˜… 5.3science fiction Β· horror

Cerebral horror, and it commits to that

Five young mutants, just discovering their abilities while held in a secret facility against their will, fight to escape their past sins and save themselves.

M3GAN poster
M3GAN
2022 Β· dir. Gerard Johnstone
πŸ… 93%β˜… 6.3science fiction Β· horror

Both lean on dread more than on science fiction

A brilliant toy company roboticist uses artificial intelligence to develop M3GAN, a life-like doll programmed to emotionally bond with her newly orphaned niece. But when the doll's programming works too well, she becomes overprotective of her new friend with terrifying results.

Doom poster
Doom
2005 Β· dir. Andrzej Bartkowiak
πŸ… 18%β˜… 5.2action Β· horror Β· science fiction

Unsettling horror in both cases

A team of space marines known as the Rapid Response Tactical Squad, led by Sarge, is sent to a science facility on Mars after somebody reports a security breach. There, they learn that the alert came after a test subject, a mass murderer purposefully injected with alien DNA, broke free and began killing people. Dr. Grimm, who is related to team member Reaper, informs them all that the chromosome can mutate humans into monsters -- and is highly infectious.

The Host poster
The Host
2006 Β· dir. Bong Joon Ho
πŸ… 93%β˜… 7.1horror Β· drama Β· science fiction

Science fiction with a pulse of ideas, in both cases

A teenage girl is captured by a giant mutated squid-like creature that appears from Seoul's Han River after toxic waste was dumped in it, prompting her family into a frantic search for her.

Brightburn poster
Brightburn
2019 Β· dir. David Yarovesky
πŸ… 57%β˜… 6.1horror Β· science fiction Β· drama

Horror built on dread, twice over

What if a child from another world crash-landed on Earth, but instead of becoming a hero to mankind, he proved to be something far more sinister?

Island of Lost Souls poster
Island of Lost Souls
1932 Β· dir. Erle C. Kenton
πŸ… 88%β˜… 7.4science fiction Β· horror

Both are built on the same subject: genetic engineering

The difference: 78 years apart, and the 1930s show

An obsessed scientist conducts profane experiments in evolution, eventually establishing himself as the self-styled demigod to a race of mutated, half-human abominations.

Shin Godzilla poster
Shin Godzilla
2016 Β· dir. Shinji Higuchi
πŸ… 87%β˜… 6.9action Β· science fiction Β· horror

Science fiction built on unease, twice over

When a massive, gilled monster emerges from the deep and tears through the city, the government scrambles to save its citizens. A rag-tag team of volunteers cuts through a web of red tape to uncover the monster's weakness and its mysterious ties to a foreign superpower. But time is not on their side - the greatest catastrophe to ever befall the world is about to evolve right before their very eyes.

#Alive poster
#Alive
2020 Β· dir. Cho Il
β˜… 6.3action Β· horror Β· science fiction

Both run cerebral where it counts

As a grisly virus rampages a city, a lone man stays locked inside his apartment, digitally cut off from seeking help and desperate to find a way out.

In the mood for more dread?

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The best-reviewed films that share Splice’s defining feeling.